The U.S. healthcare system has a long history of being unnecessarily complex, fragmented, and expensive. Within the last year, however, these challenges have only been exacerbated. The government has overhauled agencies including the National Institutes of Health and Centers for Disease Control and Prevention, slashed medical research grants, allowed for the expiration of Affordable Care Act subsidies, and defunded reproductive and gender-affirming care. Meanwhile, healthcare workers remain overburdened by staffing shortages. As the U.S. healthcare system continues to deteriorate, who is filling in the gaps? This panel highlights the companies and organizations that are stepping up and innovating at a time when old solutions are no longer reliable ones.